Author: Elodie Dubus


KNOWTOX, a Franco-Hungarian collaborative project relative to toxicity

Jun 13, 2007 - Presentation
Drug-induced hepatotoxicity or liver damage/disease is a major concern during the drug development process. Toxicity knowledge exists but data is scattered in numerous sources and can not…

Assessment of GPCR ligands Diversity Using Molecular Properties-Based Functional Radars and Fragment Analysis

May 8, 2008 - Poster
By collecting chemical structures of ligands, associated targets with all reported in vitro and in vivo pharmacological responses from the literature, we have built a GPCR knowledgebase. …

Assessing potency of c-Jun N-terminal kinase 3 (JNK3) inhibitors using 2D molecular descriptors and binary QSAR methodology

Mar 24, 2007 - Publication
JNK3 signaling pathway is gaining interest due to its involvement in many neurological disorders. The purpose of this study was to explore for the first time the use of a large and divers…

Assessing the chemical and biological diversity of an ion channels knowledge database

Sep 28, 2007 - Publication
The aim of the present work is to assess the chemical and biological diversity of ligands reported in scientific articles or patents to be active against ion channels targets. A specific …