Institution: Jagiellonian University

aleksander

Computational toxicology – in silico assessment of the hERG channel inhibition potential for the early drug cardiotoxicity testing

May 18, 2011 - Presentation
Introduction – Acquired long QT syndrome (LQTS) can lead to fatal ventricular arrhythmia and one of the most common reasons for developing LQTS seen in clinical settings as Torsade …

Application of RP-TLC technique for the determination of dissociation constants of 1-substituted pyrrolidin-2-one derivatives

Jul 23, 2008 - Publication
The procedures for measuring dissociation constants (pK(a)) of twenty 1-substituted pyrrolidin-2-one derivatives are described. The dissociation constants of the compounds tested were det…

Drugs inhibiting slow delayed rectifying potassium current (IKs) – literature data analysis and predictive model development

Dec 1, 2012 - Presentation
The excitable cell membranes contain the ion channels, what allow the ions passage through the specific pores by a passive process. Dynamic equilibrium formed on the border can be harmed …