Institution: University of Miami

Small Molecules in Big Data: Proceed with Caution!

Sep 14, 2016 - Presentation
The Schürer research group at The University of Miami is one of three sites for the Big Data to Knowledge (BD2K) Data Coordination Integration Center (DCIC) of the Library of Integrated …
chris mader

LIFE, LIFEwrx and the Library of Integrated Network-Based Cellular Signatures

Sep 25, 2013 - Presentation
The University of Miami Center for Computational Science has been developing the BioAssay Ontology (BAO), an OWL ontology, designed to make HTS assays easier interrogate. Recently the BAO…

Chemical Interrogation of the Neuronal Kinome Using a Primary Cell-Based Screening Assay

Mar 12, 2013 - Publication
A fundamental impediment to functional recovery from spinal cord injury (SCI) and traumatic brain injury is the lack of sufficient axonal regeneration in the adult central nervous system.…

Screening informatics

Jan 1, 2009 - Publication
Small molecule high throughput screening (HTS) is an industrial-like operation to identify novel entry points into drug discovery programs. In this article we discuss the functions, requi…

Novel Kinase Inhibitors by Reshuffling Ligand Functionalities Across the Human Kinome

Nov 5, 2012 - Publication
Protein kinases remain among the most versatile and prospective therapeutic drug targets with currently 15 distinct compounds approved for use in humans and numerous clinical development …

BioAssay Ontology Annotations Facilitate Cross-Analysis of Diverse High-Throughput Screening Data Sets

Jun 23, 2011 - Publication
High-throughput screening data repositories, such as PubChem, represent valuable resources for the development of small molecule chemical probes and can serve as entry points for drug dis…