LIFE, LIFEwrx and the Library of Integrated Network-Based Cellular Signatures
The University of Miami Center for Computational Science has been developing the BioAssay Ontology (BAO), an OWL ontology, designed to make HTS assays easier interrogate. Recently the BAO has also been applied to create the LIFE ontology, which is used to describe assay data being produced by the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) project. As part of both of these projects we have developed two software applications (BAOSearch and LIFEwrx) to demonstrate how these ontologies can be applied to both organize assay data and make it semantically searchable by combining both biological concepts and chemical feature information. We will present the LIFEwrx knowledge-base, describe its key features and architecture (which includes ChemAxon technology), as well as give a demonstration of the current system.